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Mount Sinai Finds New Clues to Alzheimer’s Treatment

Mount Sinai researchers have uncovered new details about how the APOE4 gene contributes to brain changes associated with Alzheimer's and other neurodegenerative diseases, identifying biological processes that could become targets for future treatments. In two studies published in Cell and Cell Stem Cell, scientists found that APOE4 can contribute to damage in cells supporting brain blood vessels while also disrupting processes involved in clearing abnormal proteins. Researchers were able to reverse some vascular changes in experimental models by blocking a specific signaling pathway. The team also used Mount Sinai's stem cell-derived miBrain platform to recreate complex human brain tissue, providing researchers with a new way to investigate disease mechanisms and potentially test therapies more efficiently.

Bronx Green Jobs Center Gets $2.5M in New Funding

Fordham University's Bronx Green Jobs Center has secured $2.5 million in new capital funding as construction moves toward completion at 585 East Fordham Road. Con Edison is providing $1.5 million to support a classroom and event space capable of accommodating up to 200 people, while Bronx Borough President Vanessa Gibson's office is providing another $1 million for renovations throughout the facility. The 12,000-square-foot center is being developed as a workforce and entrepreneurship hub focused on New York's growing green economy. Initial training programs are expected to include solar installation and repair, electric vehicle charging infrastructure, urban agriculture, energy-efficient buildings and environmental justice. Construction is expected to finish in early 2027, with programming beginning afterward.

NYU Langone Named No. 1 U.S. Health System Again

NYU Langone Health has earned the top position in Vizient's national health system rankings for the fifth consecutive year, becoming the first system to hold the organization's No. 1 ranking for five straight years. Its Manhattan campus also ranked first among 122 comprehensive academic medical centers, while NYU Langone's network of more than 400 outpatient practices placed first among 70 participating physician networks. Other facilities across the New York region also appeared in the rankings, with NYU Langone Hospital—Long Island placing No. 3 and NYU Langone Hospital—Brooklyn reaching No. 6 in their cohort. Vizient evaluates healthcare organizations using measures including safety, mortality, effectiveness, efficiency and patient experience.

190,000 NY Caregivers Seek Vote to Join 1199SEIU

Nearly 190,000 New York caregivers could participate in a union representation election after workers in the state's Consumer Directed Personal Assistance Program filed with the National Labor Relations Board seeking representation by 1199SEIU United Healthcare Workers East. Approximately 70,000 CDPAP caregivers signed union authorization cards supporting an election, according to the union. CDPAP allows eligible older adults and people with disabilities to select and direct caregivers who assist them at home, including relatives in many cases. The organizing effort comes as demand for home care workers continues to increase nationwide. Federal projections show employment of home health and personal care aides growing by approximately 847,300 jobs between 2025 and 2035, the largest projected numerical increase of any U.S. occupation

NYC Pension Funds Eye $5B in Climate Investments

New York City Comptroller Mark Levine is proposing a major expansion of private-market climate investments involving three of the city's public pension funds. Under the plan, the Comptroller's Bureau of Asset Management expects to present $5 billion in potential investments to the boards overseeing NYCERS, the Teachers' Retirement System and the Board of Education Retirement System. Opportunities would include renewable power, energy storage, grid modernization, clean transportation, energy efficiency and building upgrades. Individual investments would still require review and approval by the pension boards. The proposal is part of a broader strategy under which the three retirement systems have established a goal of investing $37.8 billion in climate-related solutions by 2035.

East New York Concert Series Draws Over 10,000

More than 10,000 people attended the fourth annual East New York Concert and Wellness Series, according to organizers. The four-day community event took place September 17 through September 20 on Van Siclen Avenue. Presented by Assemblywoman Nikki Lucas and DJ Keith Watkins, the free series combined live performances with health screenings, wellness information and community resources.

The lineup included Doug E. Fresh, Nice & Smooth, Angela Winbush, Howard Hewett, Crystal Waters, Byron Stingily, Hildemaro, DJ Famoso, Bri Babineaux, The Walls Group and numerous DJs and other performers. Each day featured a different musical focus, ranging from Caribbean and Latin music to House, Hip-Hop, R&B, Gospel and Jazz, bringing residents together from across East New York and East Brooklyn.